“Clearly, our biggest unmet need is developing treatments for progressive MS. That is the biggest hole in our treatment armamentarium,” Fox said. Among other candidates, “ibudilast is a therapy that I’ve been involved in that looks promising,” he added.
In a recent interview with Multiple Sclerosis News Today, Fox discussed the findings of the 96-week Phase 2 SPRINT-MS study (NCT01982942), which reported that use of ibudilast — an oral treatment developed by MediciNova — slowed the progression of brain atrophy by 48 percent relative to placebo in patients with either primary or secondary progressive MS (SPMS).
Although a Phase 3 trial would be essential to properly assess therapeutic benefit, this result compared favorably with those of prior studies with Ocrevus in RRMS and progressive MS, and with the investigational progressive MS treatment siponimod (by Novartis), Fox said.
“Clearly, our biggest unmet need is developing treatments for progressive MS. That is the biggest hole in our treatment armamentarium,” Fox said. Among other candidates, “ibudilast is a therapy that I’ve been involved in that looks promising,” he added.
In a recent interview with Multiple Sclerosis News Today, Fox discussed the findings of the 96-week Phase 2 SPRINT-MS study (NCT01982942), which reported that use of ibudilast — an oral treatment developed by MediciNova — slowed the progression of brain atrophy by 48 percent relative to placebo in patients with either primary or secondary progressive MS (SPMS).
Although a Phase 3 trial would be essential to properly assess therapeutic benefit, this result compared favorably with those of prior studies with Ocrevus in RRMS and progressive MS, and with the investigational progressive MS treatment siponimod (by Novartis), Fox said.