※HeptaresTL 5時間前: We are now seeking an experienced leader for our Computational Chemistry group GPCR. (6/16up)
※"Head of Computational Chemistry"
Company: Heptares Therapeutics
Published:14-Jun-2017
Heptares Therapeutics Ltd is clinical stage company using innovative techniques in protein engineering and structure-based drug design directed at G protein-coupled receptors (GPCRs).
Heptares has built an exciting pipeline of new medicines across disease areas including Alzheimer’s disease, migraine and cancer.
Our ability to address highly validated, yet historically undruggable, GPCRs has also attracted multiple partners including Allergan, AstraZeneca, Daiichi Sankyo, Kymab, Morphosys, Pfizer and Teva.
We are currently seeking an experienced leader for our computational chemistry group, which is central to our structure-based design efforts, with the motivation and leadership skills to join a world class team at Heptares Therapeutics.
Key qualifications and requirements:
・Be educated to PhD level in Chemistry or a related Physical or Biomedical science
・Be an established authority in the use of Computational Chemistry approaches to drive drug discovery programmes with a supporting publication record
・Be an expert in the application of structure-based methodology to drug discovery (SBDD) with an accomplished track record of delivery of success within small molecule drug discovery projects, driving computational chemistry contributions with a hands on approach
・Have significant experience of project management of multi-disciplinary drug discovery teams and matrix management of resource
・Have significant experience of line management, mentoring and training of staff
・Proven ability to work collaboratively in a team oriented environment
・Have advanced knowledge of the principles governing the 3D structures of proteins and ligand conformations and the interactions between them
・Have a good understanding of the principles of medicinal chemistry and compound properties, having demonstrated significant contributions to the intellectual property of drug discovery projects
・Will ideally have experience of working with GPCRs
・Will ideally have experience of leading a Computational Chemistry function
・Creative problem solver who can foresee the potential of new computational chemistry / CADD approaches
・Clear and open communicator
The successful candidate will:
・Be directly involved with drug discovery teams to identify and optimise new lead molecules using structure-based approaches
・Project manage drug discovery projects both on internal pipeline projects and in collaborations with pharma and biotech
・Ensure Computational Chemistry support for internal and partnered projects is of the highest quality and appropriately balanced, line managing the team
・Liaise with other functions within Heptares to ensure maximal impact of Computational Chemistry efforts
・Assist with the assessment of opportunities for new projects involving novel targets and/or novel drug molecules
・Represent Heptares in discussions with actual and potential collaborators and by giving presentations at international conferences
・Work with selected partners to progress target validation and drug discovery projects
・Apply new cutting-edge methodology within Computational Chemistry as applied to drug discovery
・Drive collaborations with software companies or relevant academic groups to deliver new computational chemistry capabilities customised to Heptares needs
・Ensure the Computational Chemistry methods, tools and computational resources utilised within Heptares are the most appropriate for structure-based drug discovery
・Play an influential role in the overall project management and best practice within the Discovery team at Heptares
The closing date for applications is 14th July 2017.
※HeptaresTL 5時間前: We are now seeking an experienced leader for our Computational Chemistry group GPCR. (6/16up)
※"Head of Computational Chemistry"
Company: Heptares Therapeutics
Published:14-Jun-2017
Heptares Therapeutics Ltd is clinical stage company using innovative techniques in protein engineering and structure-based drug design directed at G protein-coupled receptors (GPCRs).
Heptares has built an exciting pipeline of new medicines across disease areas including Alzheimer’s disease, migraine and cancer.
Our ability to address highly validated, yet historically undruggable, GPCRs has also attracted multiple partners including Allergan, AstraZeneca, Daiichi Sankyo, Kymab, Morphosys, Pfizer and Teva.
We are currently seeking an experienced leader for our computational chemistry group, which is central to our structure-based design efforts, with the motivation and leadership skills to join a world class team at Heptares Therapeutics.
Key qualifications and requirements:
・Be educated to PhD level in Chemistry or a related Physical or Biomedical science
・Be an established authority in the use of Computational Chemistry approaches to drive drug discovery programmes with a supporting publication record
・Be an expert in the application of structure-based methodology to drug discovery (SBDD) with an accomplished track record of delivery of success within small molecule drug discovery projects, driving computational chemistry contributions with a hands on approach
・Have significant experience of project management of multi-disciplinary drug discovery teams and matrix management of resource
・Have significant experience of line management, mentoring and training of staff
・Proven ability to work collaboratively in a team oriented environment
・Have advanced knowledge of the principles governing the 3D structures of proteins and ligand conformations and the interactions between them
・Have a good understanding of the principles of medicinal chemistry and compound properties, having demonstrated significant contributions to the intellectual property of drug discovery projects
・Will ideally have experience of working with GPCRs
・Will ideally have experience of leading a Computational Chemistry function
・Creative problem solver who can foresee the potential of new computational chemistry / CADD approaches
・Clear and open communicator
The successful candidate will:
・Be directly involved with drug discovery teams to identify and optimise new lead molecules using structure-based approaches
・Project manage drug discovery projects both on internal pipeline projects and in collaborations with pharma and biotech
・Ensure Computational Chemistry support for internal and partnered projects is of the highest quality and appropriately balanced, line managing the team
・Liaise with other functions within Heptares to ensure maximal impact of Computational Chemistry efforts
・Assist with the assessment of opportunities for new projects involving novel targets and/or novel drug molecules
・Represent Heptares in discussions with actual and potential collaborators and by giving presentations at international conferences
・Work with selected partners to progress target validation and drug discovery projects
・Apply new cutting-edge methodology within Computational Chemistry as applied to drug discovery
・Drive collaborations with software companies or relevant academic groups to deliver new computational chemistry capabilities customised to Heptares needs
・Ensure the Computational Chemistry methods, tools and computational resources utilised within Heptares are the most appropriate for structure-based drug discovery
・Play an influential role in the overall project management and best practice within the Discovery team at Heptares
The closing date for applications is 14th July 2017.