ネクセラファーマ(株)【4565】の掲示板 2017/05/24〜2017/05/26

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※Novartis: New analyses reinforce the potential of Ultibro Breezhaler for COPD patients historically treated with steroids. (5/23)
※Sunovion: Announces Utibron Neohaler Inhalation Powder Data Showing Lung Function and Health-Related Quality of Life Improvement in Patients with Moderate-to-Severe COPD. (5/23)

※SOSEI：FLAME試験データの新たな解析により、ステロイド使用歴のあるCOPD患者に対するウルティブロブリーズヘラーの有用性が再認識された。(5/24日付：5/25 19:58)

※米国特許出願：Mutant G-Protein Coupled Receptor Proteins and Methods for Producing Them. (5/25公開)
・Document Type and Number: United States Patent Application 20170145075 A1
・Publication Date: 05/25/2017
・Assignee: Heptares Therapeutics Limited
・Abstract:
A method for producing a mutant G-protein coupled receptor (GPCR) with increased stability relative to a parent GPCR, the method comprising making one or more mutations in the amino acid sequence that defines a Class 1 parent GPCR, wherein
(i) the one or more mutations are located within a window of i plus or minus 5 residues, where i is the position of amino acid residue 3.55 in the parent GPCR, and/or
(ii) the one or more mutations are located within a window of i minus 2 to i residues, where i is the position of amino acid residue 5.63 in the parent GPCR, and/or
(iii) the one or more mutations are located within a window of i minus 4 to i plus 1 residues, where i is the position of amino acid residue 7.42 in the parent GPCR, to provide one or more mutants of the parent GPCR with increased stability.
ttp://www.freepatentsonline.com/20170145075.pdf