COVID-19 is a life threatening novel corona viral infection to our civilization and spreading rapidly. Terrific efforts are giving by the researchers to control the rate of mortality. Here, a series of arsenical derivatives were optimized and analyzed with in silico
study to search the inhibitor of novel-corona viral replication or to stop the life cycle. All the derivatives were blindly docked using iGEMDOCK v2.1 individually with RNA dependent RNA polymerase (RdRp) of SARS-
CoV-2, is the main component of viral replication and
appears to be the primary target of antiviral drugs. Based on the lower idock score in the catalytic pocket of RdRp, darinaparsin (-82.52 kcal/mol) revealed most effective among them. Darinaparsin strongly binds with both Nsp9 replicase protein (8.77 kcal/mol) and
Nsp15 endoribonuclease (-8.3 kcal/mol) of SARS-CoV
-2 as confirmed from the AutoDock analysis.
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ダリナパルシンについて確かに海外の記事がありました。深く読んでいないので細かい所は解らないのですがコロナの活動の抑止になるみたいですね。以下序文です。
Abstract
COVID-19 is a life threatening novel corona viral infection to our civilization and spreading rapidly. Terrific efforts are giving by the researchers to control the rate of mortality. Here, a series of arsenical derivatives were optimized and analyzed with in silico
study to search the inhibitor of novel-corona viral replication or to stop the life cycle. All the derivatives were blindly docked using iGEMDOCK v2.1 individually with RNA dependent RNA polymerase (RdRp) of SARS-
CoV-2, is the main component of viral replication and
appears to be the primary target of antiviral drugs. Based on the lower idock score in the catalytic pocket of RdRp, darinaparsin (-82.52 kcal/mol) revealed most effective among them. Darinaparsin strongly binds with both Nsp9 replicase protein (8.77 kcal/mol) and
Nsp15 endoribonuclease (-8.3 kcal/mol) of SARS-CoV
-2 as confirmed from the AutoDock analysis.