UW Medicine enrolling patients for COVID-19 test therapies
The ACTIV-2 trial is studying multiple treatments in parallel for people who have early, symptomatic cases.
ACTIV-2 will study these agents among non-hospitalized adults with COVID-19:
AZD7442, developed by AstraZeneca, is a combination of two monoclonal antibodies (AZD8895 and AZD1061). It is being studied as both an infusion and intramuscular injection. Both drugs were developed from antibodies of individuals who had recovered from COVID-19. The test therapy targets the spike protein of SARS-CoV-2 and is thought to bemore stable and longer-acting than other monoclonals being studied.
SNG001, developed by Synairgen, is a nebulized formulation of beta interferon being studied as an inhalant. SNG001 will be self-administered as a spray that participants inhale once daily for 14 days. Participants will be trained to use the nebulizer device and will take all doses at home. ACTIV-2 is the first U.S. study to evaluate SNG001 among non-hospitalized people with COVID-19.
Camostat, provided by Sagent Pharmaceuticals, is an orally administered protease inhibitor taken in 200 mg doses every six hours for seven days. Camostat inhibits TMPRSS2, a host cell protease that facilitates SARS-CoV-2 binding and entry into the host cell. Participants will take the first dose of Camostat at enrollment and subsequent doses at home.
UW Medicine enrolling patients for COVID-19 test therapies
The ACTIV-2 trial is studying multiple treatments in parallel for people who have early, symptomatic cases.
ACTIV-2 will study these agents among non-hospitalized adults with COVID-19:
AZD7442, developed by AstraZeneca, is a combination of two monoclonal antibodies (AZD8895 and AZD1061). It is being studied as both an infusion and intramuscular injection. Both drugs were developed from antibodies of individuals who had recovered from COVID-19. The test therapy targets the spike protein of SARS-CoV-2 and is thought to bemore stable and longer-acting than other monoclonals being studied.
SNG001, developed by Synairgen, is a nebulized formulation of beta interferon being studied as an inhalant. SNG001 will be self-administered as a spray that participants inhale once daily for 14 days. Participants will be trained to use the nebulizer device and will take all doses at home. ACTIV-2 is the first U.S. study to evaluate SNG001 among non-hospitalized people with COVID-19.
Camostat, provided by Sagent Pharmaceuticals, is an orally administered protease inhibitor taken in 200 mg doses every six hours for seven days. Camostat inhibits TMPRSS2, a host cell protease that facilitates SARS-CoV-2 binding and entry into the host cell. Participants will take the first dose of Camostat at enrollment and subsequent doses at home.