In conclusion, vaccination with the CPV S-588410 induces functional CD8+ and CD4+ TILs and PD-L1 expression in esophageal cancer. The CD8+ TILs are derived from antigen-specific CTLs in blood, and an increase of CD8+ Granzyme B+ cells in tumors could lead to antitumor activity. The production of IFN-γ from CTLs may offer a mechanism for establishing an inflamed TME characterized by high PD-L1 expression. Therefore, a combination of S-588410 with anti-PD-(L)1 antibodies may be expected to have a synergistic effect.
In conclusion, vaccination with the CPV S-588410 induces functional CD8+ and CD4+ TILs and PD-L1 expression in esophageal cancer. The CD8+ TILs are derived from antigen-specific CTLs in blood, and an increase of CD8+ Granzyme B+ cells in tumors could lead to antitumor activity. The production of IFN-γ from CTLs may offer a mechanism for establishing an inflamed TME characterized by high PD-L1 expression. Therefore, a combination of S-588410 with anti-PD-(L)1 antibodies may be expected to have a synergistic effect.
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なんて書いてあるかわかりません。