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そーせいグループ(株)【4565】の掲示板 2017/06/17〜2017/06/21

※HeptaresTL 23分前: We are now seeking an experienced DMPK Leader GPCR. (6/21up)

"DMPK Leader (Associate Director/Director) "
Company: Heptares Therapeutics
Published:21-Jun-2017

We are seeking a highly experienced Discovery DMPK leader to influence project direction, and provide strategic and scientific DMPK leadership across the Heptares portfolio.

Heptares Therapeutics is an established UK biotech company with world-class technology in structure-based drug design applied to discovery of novel small molecules acting through GPCRs.

The company works in collaboration with major global pharmaceutical companies on both small molecule and antibody discovery programmes, and is also developing its own pipeline of new chemical entities.
The most advanced of these is now in Phase I clinical studies with others moving towards clinical development.
The company is currently based in Welwyn Garden City; has approximately 100 employees and has been operating for ten years.
The size of the company ensures a transparent linkage between all activities from early discovery through to clinical development.

As a result of increased activities in building its own pipeline we are seeking to recruit a DMPK Associate Director or Director to support Heptares projects throughout discovery phases up to pre-clinical candidate (PCC) selection.

As a recognised DMPK leader you will have extensive experience of supporting DMPK across discovery and into early development incorporating state of the art methodologies to drive clear, effective decision-making.
Working through a recognized network of external suppliers and consultants and in close collaboration with medicinal chemists you will have overall responsibility for progressing molecules with appropriate DMPK properties, from early discovery through lead optimisation to pre-clinical candidate nomination.
The successful candidate will play a key role in our collaboration drug discovery partnerships and there will be potential to work with our Development team to support aspects of the clinical progression of our pipeline.

For the right candidate, the role provides a great opportunity to work with senior management to develop and apply this capability in a rapidly growing company on scientifically challenging issues.

Required skills and qualifications:
・A PhD in pharmaceutical sciences, DMPK or related disciplines, with 5-10 years previous pharmaceutical or biotech industry experience in DMPK including project management, pre-clinical drug discovery (experience of drug development and clinical exposure predictions is highly desirable)
・A demonstrated track record of success through involvement in successful drug discovery projects and from peer-reviewed publications
・The ability to work flexibly and efficiently across a variety of therapeutic areas with specific expertise optimizing DMPK properties to support CNS exposure and alternative routes of administration
・Excellent working knowledge, and hands-on experience of software packages to enable PBPK and PKPD modelling for purposes of human PK and dose predictions (such as WinNonLin/Phoenix, GastroPlus)
・Strong experience of both line and matrix management within DMPK and project teams
・Proven ability to lead projects with strategic oversight and act as an ambassador for the group
・Excellent communication and interaction skills and demonstrated capability to operate in a proactive, collaborative and entrepreneurial biotech culture; and able to act both strategically and operationally

The closing date for applications is 19th July 2017.